Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2479501 | 0.75 | MLNR (0.40) | — | |
| SCHEMBL592970 | 0.74 | KDM4E (0.58) | KDM4ECHRM3KMT2AMEN1TSHR | |
| SCHEMBL1064531 | 0.74 | ALDH1A1 (0.71) | ALDH1A1KDM4EKMT2AMEN1HTT | |
| Hydrochloric Acid SCHEMBL10922202 | 0.73 | KDM4E (0.57) | KDM4ECHRM3KMT2AMEN1TSHR | |
| SCHEMBL27683362 | 0.73 | ALDH1A1 (0.56) | ALDH1A1KDM4EKMT2AMEN1HTT | |
| SCHEMBL8231916 | 0.72 | SLC18A3 (0.60) | ALDH1A1KDM4EKMT2AMEN1TSHR | |
| SCHEMBL14197728 | 0.72 | TSHR (0.56) | ALDH1A1KDM4ELMNATSHRSLC18A3 | |
| SCHEMBL25640538 | 0.72 | LMNA (0.51) | ALDH1A1KDM4ECHRM3HTTTDP1 | |
| SCHEMBL25743441 | 0.72 | LMNA (0.51) | ALDH1A1KDM4ECHRM3HTTTDP1 | |
| SCHEMBL108678 | 0.72 | KDM4E (0.70) | KDM4EKMT2AMEN1TSHRSLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1429765-A2 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003024448-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2003-03-27 | — | — | WO | disclosed |