Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5043421 | 0.92 | CRHR1 (0.31) | CRHR1POLB | |
| SCHEMBL6645359 | 0.92 | ACHE (0.35) | ACHECRHR1HPGDNPSR1KDM4E | |
| SCHEMBL5039764 | 0.84 | CRHR1 (0.32) | CRHR1 | |
| SCHEMBL5048460 | 0.84 | CRHR1 (0.39) | CRHR1HPGDNPSR1KDM4ELMNA | |
| SCHEMBL5039172 | 0.82 | GAA (0.44) | CRHR1NPSR1POLBHTTSMN1; SMN2 | |
| SCHEMBL5045685 | 0.80 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL6053104 | 0.80 | CRHR1 (0.47) | ACHECRHR1HPGDKDM4ELMNA | |
| SCHEMBL6303475 | 0.79 | CRHR1 (0.47) | ACHECRHR1KDM4ELMNAPOLB | |
| SCHEMBL5522195 | 0.79 | CRHR1 (0.33) | CRHR1NR1I2 | |
| SCHEMBL5043583 | 0.78 | TSHR (0.38) | CRHR1HPGDKDM4EPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453832-A1 | RING FUSED PYRAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2004-09-08 | — | — | EP | claimed |
| WO-2003048160-A1 | RING FUSED PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-12 | — | — | WO | claimed |