Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALPG | P10696 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039764 | 0.92 | CRHR1 (0.32) | CRHR1 | |
| SCHEMBL6645857 | 0.92 | ACHE (0.36) | ACHECRHR1HPGDNPSR1KDM4E | |
| SCHEMBL5043421 | 0.84 | CRHR1 (0.31) | CRHR1 | |
| SCHEMBL6646487 | 0.83 | CRHR1 (0.34) | CRHR1 | |
| SCHEMBL6648719 | 0.82 | RXRA (0.35) | CRHR1KDM4EALDH1A1 | |
| SCHEMBL5518409 | 0.82 | CRHR1 (0.35) | CRHR1 | |
| SCHEMBL5048617 | 0.80 | TSHR (0.44) | CRHR1HPGDALDH1A1 | |
| SCHEMBL5520250 | 0.78 | RXRA (0.38) | CRHR1HPGDALDH1A1 | |
| SCHEMBL14031211 | 0.78 | PKM (0.33) | CRHR1 | |
| SCHEMBL5039393 | 0.77 | CRHR1 (0.32) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453832-A1 | RING FUSED PYRAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2004-09-08 | — | — | EP | claimed |
| WO-2003048160-A1 | RING FUSED PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-12 | — | — | WO | claimed |
| EP-1453832-A1 | RING FUSED PYRAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003048160-A1 | RING FUSED PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-12 | — | — | WO | disclosed |