Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 2/20 | 0.50 |
| ▸ | FEN1 | P39748 | 2/20 | 0.50 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6650059 | 0.92 | KMT2A (0.43) | ERCC1FEN1ERCC4KMT2AMEN1 | |
| SCHEMBL6647993 | 0.91 | TNKS (0.49) | ERCC1FEN1ERCC4KMT2AMEN1 | |
| SCHEMBL6645790 | 0.85 | ERCC1 (0.53) | ERCC1FEN1ERCC4KMT2AMEN1 | |
| SCHEMBL6649378 | 0.81 | ERCC1 (0.58) | ERCC1FEN1ERCC4TNKSPIN1 | |
| SCHEMBL6645901 | 0.78 | ERCC1 (0.47) | ERCC1FEN1ERCC4KMT2AMEN1 | |
| SCHEMBL6883598 | 0.78 | TNKS (0.43) | ERCC1FEN1ERCC4KMT2ATNKS | |
| SCHEMBL6644556 | 0.76 | KMT2A (0.51) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL6647393 | 0.75 | HSD17B10 (0.46) | ERCC1FEN1ERCC4KMT2AMEN1 | |
| SCHEMBL6881534 | 0.75 | PIN1 (0.70) | ERCC1FEN1ERCC4KMT2AMEN1 | |
| SCHEMBL6885410 | 0.75 | PIN1 (0.60) | ERCC1FEN1ERCC4PIN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441735-A1 | N-SUBSTITUTED HYDROXYPYRIMIDINONE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2004-08-04 | — | — | EP | claimed |
| WO-2003035077-A1 | N-SUBSTITUTED HYDROXYPYRIMIDINONE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2003-05-01 | — | — | WO | claimed |