Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6650063 | 0.92 | ROCK2 (0.44) | ERCC1FEN1ERCC4ROCK2ROCK1 | |
| SCHEMBL6645792 | 0.84 | ERCC1 (0.52) | ERCC1FEN1ERCC4ROCK2ROCK1 | |
| SCHEMBL6649380 | 0.81 | ERCC1 (0.54) | ERCC1FEN1ERCC4PDE2ACSF1R | |
| SCHEMBL6645899 | 0.78 | ERCC1 (0.50) | ERCC1FEN1ERCC4KMT2AMEN1 | |
| SCHEMBL5113700 | 0.77 | ROCK2 (0.52) | ROCK2ROCK1MAOBKMT2AMEN1 | |
| SCHEMBL1150469 | 0.76 | ROCK2 (0.47) | ROCK2ROCK1MAOBKMT2AMEN1 | |
| SCHEMBL6884591 | 0.74 | ERCC1 (0.50) | ERCC1FEN1ERCC4KMT2AMEN1 | |
| SCHEMBL6017819 | 0.71 | LMNA (0.48) | GAA | |
| SCHEMBL6650059 | 0.71 | KMT2A (0.43) | ERCC1FEN1ERCC4KMT2AMEN1 | |
| SCHEMBL5127969 | 0.70 | MAOB (0.48) | ROCK2ROCK1MAOBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441735-A1 | N-SUBSTITUTED HYDROXYPYRIMIDINONE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2004-08-04 | — | — | EP | claimed |
| WO-2003035077-A1 | N-SUBSTITUTED HYDROXYPYRIMIDINONE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2003-05-01 | — | — | WO | claimed |