Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 4/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.37 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172629 | 0.89 | CHRNB4 (0.51) | CHRNB4CHRNA3CHEK1PRKCZGAA | |
| SCHEMBL7006966 | 0.89 | CHRNB4 (0.55) | CHRNB4CHRNA3CHEK1PRKCZGAA | |
| SCHEMBL6628961 | 0.85 | CHRNB4 (0.51) | CHRNB4CHRNA3CHEK1GAAKDM4E | |
| SCHEMBL6073607 | 0.85 | CHRNB4 (0.47) | CHRNB4CHRNA3CHEK1GAAKDM4E | |
| SCHEMBL12491869 | 0.80 | CHRNB4 (0.39) | CHRNB4CHRNA3CHEK1MKNK1PRKCZ | |
| SCHEMBL5239690 | 0.80 | SSTR2 (0.41) | CHRNB4CHRNA3MKNK1PRKCZSSTR2 | |
| SCHEMBL4705249 | 0.80 | SLC6A2 (0.39) | CHRNB4CHRNA3MKNK1PRKCZ | |
| SCHEMBL6646923 | 0.80 | GAA (0.51) | CHRNB4CHRNA3CHEK1GAAKDM4E | |
| SCHEMBL5261782 | 0.77 | PRKCZ (0.37) | CHRNB4CHRNA3CHEK1MKNK1PRKCZ | |
| SCHEMBL5262749 | 0.76 | SSTR2 (0.39) | KDM4EHTTSSTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436267-A1 | LACTAM DERIVATIVES AS ANTAGONISTS FOR HUMAN 11CBY RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003033480-A1 | LACTAM DERIVATIVES AS ANTAGONISTS FOR HUMAN 11CBY RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2003-04-24 | — | — | WO | disclosed |