Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 6/20 | 0.48 |
| ▸ | KCNJ11 | Q14654 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.38 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6613905 | 0.93 | P2RX7 (0.49) | P2RX7KCNJ11L3MBTL1ALDH1A1SCN5A | |
| SCHEMBL6612978 | 0.91 | P2RX7 (0.58) | P2RX7KCNJ11MEN1KMT2AL3MBTL1 | |
| SCHEMBL4685949 | 0.82 | KCNJ11 (0.57) | P2RX7KCNJ11MEN1KMT2AL3MBTL1 | |
| SCHEMBL4685946 | 0.82 | KCNJ11 (0.57) | P2RX7KCNJ11MEN1KMT2AL3MBTL1 | |
| SCHEMBL6646019 | 0.81 | MEN1 (0.48) | KCNJ11MEN1KMT2AABCC9ABCC8 | |
| SCHEMBL6642968 | 0.81 | MEN1 (0.44) | KCNJ11MEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL6644164 | 0.78 | RAB9A (0.55) | P2RX7KCNJ11MEN1KMT2AL3MBTL1 | |
| SCHEMBL6613378 | 0.78 | KCNQ3 (0.57) | KCNJ11ABCC9ABCC8KCNJ8 | |
| SCHEMBL6612971 | 0.77 | KCNJ11 (0.59) | KCNJ11ABCC9ABCC8KCNJ8CYP2D6 | |
| SCHEMBL7691318 | 0.77 | KCNJ11 (0.57) | KCNJ11ABCC9ABCC8KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |