SCHEMBL6646137

SCHEMBL6646137

N#Cc1ccc2c(c1)C1CCCC1C(N)=C2

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 1/20 0.56
NOS1 P29475 1/20 0.56
NOS2 P35228 1/20 0.56
PTGDR2 Q9Y5Y4 1/20 0.36
CHRNA1 P02708 1/20 0.36
CHRNG P07510 1/20 0.36
CHRNB1 P11230 1/20 0.36
CHRNB2 P17787 1/20 0.36
CHRNB4 P30926 1/20 0.36
CHRNA3 P32297 1/20 0.36
CHRNA4 P43681 1/20 0.36
CHRND Q07001 1/20 0.36
SLC6A4 P31645 9/20 0.35
SLC6A2 P23975 1/20 0.35
SLC6A3 Q01959 1/20 0.35
AR P10275 2/20 0.34
KDM1A O60341 3/20 0.34
GRIA4 P48058 1/20 0.34
DRD2 P14416 1/20 0.34
DRD3 P35462 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6645425 0.72 NOS1 (1.00) NOS3NOS1NOS2
SCHEMBL6646269 0.69 NOS1 (0.79) NOS3NOS1NOS2
SCHEMBL6640561 0.66 NOS3 (0.48) NOS3NOS1NOS2PTGDR2CHRNA1
SCHEMBL6641768 0.66 GSK3B (0.48) NOS3NOS1NOS2PTGDR2CHRNA1
SCHEMBL1081422 0.65 NOS3 (0.46) NOS3NOS1NOS2PTGDR2CHRNA1
SCHEMBL16905238 0.65 CHRNA1 (0.59) NOS3NOS1NOS2PTGDR2CHRNA1
SCHEMBL23204992 0.65 KDM1A (0.38) NOS3NOS1NOS2KDM1ADRD2
Hydrochloric Acid SCHEMBL7975433 0.64 NOS3 (0.45) NOS3NOS1NOS2PTGDR2CHRNA1
SCHEMBL24791025 0.62 CHRNA1 (0.50) NOS3NOS1NOS2CHRNA1CHRNG
SCHEMBL19207348 0.62 CHRNA1 (0.50) NOS3NOS1NOS2CHRNA1CHRNG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1054869-B1 3,4-DIHYDROQUINOLINE DERIVATIVES AS NITROGEN MONOXIDE SYNTHASE (NOS) INHIBITORS SCHERING AG (DE) 2004-09-22 EP disclosed