Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | KCNH3 | Q9ULD8 | 3/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11637357 | 0.94 | MAPT (0.61) | ALDH1A1MAPTKCNH3POLBGAA | |
| SCHEMBL11637424 | 0.92 | MAPT (0.59) | ALDH1A1MAPTKCNH3POLBGAA | |
| SCHEMBL11634715 | 0.92 | MAPT (0.59) | ALDH1A1MAPTKCNH3POLBGAA | |
| SCHEMBL632952 | 0.87 | KCNH3 (0.62) | ALDH1A1MAPTKCNH3GAAL3MBTL1 | |
| SCHEMBL7794562 | 0.82 | MAPT (0.61) | ALDH1A1MAPTKCNH3POLBGAA | |
| SCHEMBL14982724 | 0.80 | KCNH3 (0.51) | ALDH1A1MAPTKCNH3POLBGAA | |
| SCHEMBL18867064 | 0.80 | ALDH1A1 (0.59) | ALDH1A1MAPTKCNH3POLBMAPK1 | |
| SCHEMBL11312557 | 0.80 | KCNH3 (0.44) | ALDH1A1MAPTKCNH3GAAMAPK1 | |
| SCHEMBL9015900 | 0.80 | KCNH3 (0.51) | ALDH1A1MAPTKCNH3POLBGAA | |
| SCHEMBL13450943 | 0.80 | F2 (0.50) | ALDH1A1MAPTKCNH3POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903436-B1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF NEURODEGENERATIVE TAUOPATHIES | UNIV PENNSYLVANIA (US) | 2019-07-17 | — | — | EP | disclosed |
| US-10227295-B2 | Selective histone deactylase 6 inhibitors | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2019-03-12 | — | — | US | disclosed |
| US-9956192-B2 | Selective histone deactylase 6 inhibitors | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-05-01 | — | — | US | disclosed |
| US-20170369428-A1 | SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. | 2017-12-28 | — | — | US | disclosed |
| EP-3219207-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF NEURODEGENERATIVE TAUOPATHIES | The Trustees Of The University Of Pennsylvania (US) | 2017-09-20 | — | — | EP | disclosed |
| US-9751832-B2 | Selective histone deactylase 6 inhibitors | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-20170173016-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF NEURODEGENERATIVE TAUOPATHIES | NIH - DEITR | 2017-06-22 | — | — | US | disclosed |
| US-9649317-B2 | Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-05-16 | — | — | US | disclosed |
| US-20170035710-A1 | SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. | 2017-02-09 | — | — | US | disclosed |
| US-9409858-B2 | Selective histone deactylase 6 inhibitors | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2016-08-09 | — | — | US | disclosed |
| US-4148805-A | POLYESTERS, RED, YELLLOW | CIBA-GEIGY AG (CH) | 1979-04-10 | — | — | US | disclosed |
| US-4115381-A | FOR POLYESTER FIBERS | CIBA-GEIGY CORPORATION (US) | 1978-09-19 | — | — | US | disclosed |
| US-4083688-A | DISPERSE DYES | CIBA-GEIGY AG (CH) | 1978-04-11 | — | — | US | disclosed |
| US-4076849-A | AROMATIC SECONDARY AMINES | CANADA PACKERS LIMITED (CA) | 1978-02-28 | — | — | US | disclosed |
| US-4039529-A | Cycloaliphatic dicarbonyl containing azo dyestuffs | CIBA-GEIGY AG (CH) | 1977-08-02 | — | — | US | disclosed |
| US-3971771-A | DYES FOR POLYESTERS | CIBA-GEIGY AG (CH) | 1976-07-27 | — | — | US | disclosed |
| US-3964862-A | Process for dyeing and printing textile materials of synthetic organic fibers | CIBA-GEIGY AG (CH) | 1976-06-22 | — | — | US | disclosed |
| US-3954398-A | Polyester fibers dyed with a disazo disperse dyestuff | CIBA-GEIGY AG (CH) | 1976-05-04 | — | — | US | disclosed |
| US-3945989-A | Fluoro triazine containing water insoluble azo dyestuff | CIBA-GEIGY AG (CH) | 1976-03-23 | — | — | US | disclosed |
| US-3933786-A | Heterocyclic-azo-phenyl compounds containing a styrl group | CIBA-GEIGY AG (CH) | 1976-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170173016-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF NEURODEGENERATIVE TAUOPATHIES | MAPT, PRNP, PSEN2 | ALDH1A1 2537/4885MAPT 1/4885KCNH3 2825/4885 |
| US-20170035710-A1 | SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS | HDAC1, HDAC5, HDAC11 | ALDH1A1 389/4885MAPT 3315/4885KCNH3 3607/4885 |
| US-20170369428-A1 | SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS | HDAC1, HDAC5, HDAC11 | ALDH1A1 425/4885MAPT 3117/4885KCNH3 3598/4885 |
| US-10227295-B2 | Selective histone deactylase 6 inhibitors | HDAC1, HDAC5, HDAC11 | ALDH1A1 425/4885MAPT 3117/4885KCNH3 3598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.