SCHEMBL6646376

SCHEMBL6646376

CC(C)C(=O)c1cncnc1C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 1/20 0.39
ITGB1 P05556 1/20 0.36
ITGA4 P13612 1/20 0.36
SYK P43405 1/20 0.34
NTRK1 P04629 7/20 0.33
VNN1 O95497 2/20 0.33
KDM4E B2RXH2 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
WDR5 P61964 1/20 0.32
PDK2 Q15119 1/20 0.32
LIMK1 P53667 1/20 0.31
ATF1 P18846 2/20 0.31
NFKB1 P19838 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8574991 0.81 NFKB1 (0.40) MGLLITGB1ITGA4SYKKDM4E
SCHEMBL1671209 0.79 ASPH (0.43) MGLLITGB1ITGA4SYKVNN1
SCHEMBL23631773 0.77 SYK (0.48) MGLLITGB1ITGA4SYKKDM4E
SCHEMBL1672704 0.77 ATF1 (0.42) MGLLITGB1ITGA4SYKKDM4E
SCHEMBL13531238 0.77 MAPT (0.46) MGLLKDM4E
Trimethylammonium SCHEMBL8543218 0.75 ASPH (0.38) MGLLITGB1ITGA4SYKKDM4E
SCHEMBL8581181 0.75 MGLL (0.36) MGLLITGB1ITGA4SYKNTRK1
Trimethylammonium SCHEMBL8541657 0.75 ASPH (0.38) MGLLITGB1ITGA4SYKKDM4E
SCHEMBL8005261 0.75 ABL1 (0.34) KDM4E
SCHEMBL6646232 0.74 MALT1 (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6806230-B1 NITROGEN COMPOUNDS SUCH AS N-METHYL-N-(2-METHYL-1-(4-TRIFLUORO METHYLPYRIMIDIN-5-YL)PROPYL)PHENYLACETAMIDE, USED FOR PREFERENTIAL CONTROL OF WEEDS KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2004-10-19 US disclosed
EP-1211246-B1 PYRIMIDINE DERIVATIVES AND HERBICIDES CONTAINING THE SAME KUMIAI CHEMICAL INDUSTRY CO (JP) 2004-02-25 EP disclosed
EP-1211246-A1 PYRIMIDINE DERIVATIVES AND HERBICIDES CONTAINING THE SAME KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2002-06-05 EP disclosed