Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TXN | P10599 | 1/20 | 0.32 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 2/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10574839 | 0.78 | — | — | |
| SCHEMBL2787025 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL2699935 | 0.72 | ALDH1A1 (0.33) | FDPSALDH1A1SMN1; SMN2 | |
| SCHEMBL7556283 | 0.72 | GDA (0.40) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2625552 | 0.71 | — | — | |
| SCHEMBL2787049 | 0.71 | ALDH1A1 (0.32) | FDPSALDH1A1SMN1; SMN2 | |
| SCHEMBL2633430 | 0.69 | ALDH1A1 (0.39) | FDPSALDH1A1SMN1; SMN2KDM4ETXN | |
| SCHEMBL22408544 | 0.69 | CASP6 (0.47) | LRRK2ALDH1A1SMN1; SMN2KDM4ETRPM8 | |
| SCHEMBL7872469 | 0.69 | TAAR1 (0.41) | JAK2JAK1 | |
| SCHEMBL10072452 | 0.69 | LRRK2 (0.44) | LRRK2FDPSSMN1; SMN2PDE10ATRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448534-A1 | 6-MEMBERED UNSATURATED HETEROCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OFTHE COAGULATION CASCADE | Pharmacia Corporation (US) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003029224-A1 | 6-MEMBERED UNSATURATED HETEROCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |