Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 5/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4158770 | 0.72 | MEN1 (0.51) | TAAR1KMT2AJAK2JAK1 | |
| SCHEMBL13939838 | 0.70 | GPR84 (0.47) | — | |
| SCHEMBL3647566 | 0.70 | HTT (0.40) | TAAR1AOC3KMT2A | |
| SCHEMBL6647148 | 0.69 | JAK2 (0.40) | JAK2JAK1 | |
| SCHEMBL22524173 | 0.69 | LMNA (0.44) | TAAR1AOC3KMT2APOLB | |
| SCHEMBL3773150 | 0.68 | TAAR1 (0.53) | TAAR1HRH4 | |
| SCHEMBL1522424 | 0.67 | HTT (0.60) | KMT2AJAK3JAK2JAK1 | |
| SCHEMBL7878663 | 0.67 | NISCH (0.43) | TAAR1DAO | |
| SCHEMBL10569996 | 0.66 | ALDH1A1 (0.38) | KMT2A | |
| SCHEMBL11393997 | 0.66 | TAAR1 (0.52) | TAAR1AOC3KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086122-A1 | PYRAZINONE PROTEASE INHIBITORS | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (US) | 2001-03-28 | — | — | EP | claimed |
| WO-1999064446-A1 | PYRAZINONE PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1999-12-16 | — | — | WO | claimed |