SCHEMBL6647486

SCHEMBL6647486

Cc1ccc(C(=O)Nc2ccc(NCCc3cccc(N)n3)cc2)c(N2CCC(C)CC2)n1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SCN10A Q9Y5Y9 4/20 0.46
MAPT P10636 4/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
POLB P06746 2/20 0.41
ALDH1A1 P00352 3/20 0.41
TRPV1 Q8NER1 1/20 0.40
SMN1; SMN2 Q16637 4/20 0.39
GAA P10253 2/20 0.39
KDM4E B2RXH2 2/20 0.39
KIF18A Q8NI77 4/20 0.38
TP53 P04637 2/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
OGA O60502 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6647116 0.91 SCN10A (0.46) SCN10AMAPTMEN1KMT2APOLB
SCHEMBL6646383 0.88 SCN10A (0.47) SCN10AMAPTMEN1KMT2APOLB
SCHEMBL6645777 0.88 SCN10A (0.43) SCN10AMAPTMEN1KMT2APOLB
SCHEMBL6644190 0.88 OGA (0.52) SCN10AMAPTMEN1KMT2APOLB
SCHEMBL6646849 0.86 SCN10A (0.41) SCN10AMAPTMEN1KMT2APOLB
SCHEMBL6649970 0.86 ADRB2 (0.43) MAPTMEN1KMT2APOLBALDH1A1
SCHEMBL6647760 0.80 SCN10A (0.45) SCN10AMAPTMEN1KMT2APOLB
SCHEMBL6648073 0.80 SCN10A (0.43) SCN10AMAPTMEN1KMT2APOLB
SCHEMBL6645122 0.80 OGA (0.59) MAPTMEN1KMT2APOLBALDH1A1
SCHEMBL6643435 0.80 SCN10A (0.41) SCN10AMAPTMEN1KMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040133008-A1 Amide compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-07-08 US disclosed
WO-2004039795-A2 AMIDE COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-05-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040133008-A1 Amide compounds APOB, APOL1, LDLR SCN10A 1201/4885MAPT 4101/4885MEN1 3820/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.