Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8923648 | 0.86 | POLB (0.49) | ALDH1A1HSD17B10L3MBTL1HPGDMAPK1 | |
| SCHEMBL3077375 | 0.76 | SIRT1 (0.77) | SIRT1ALDH1A1HSD17B10L3MBTL1HPGD | |
| SCHEMBL6630237 | 0.76 | SIRT1 (0.53) | SIRT1ALDH1A1HSD17B10HPGDMAPK1 | |
| SCHEMBL6633843 | 0.73 | SIRT1 (0.53) | SIRT1ALDH1A1HSD17B10HPGDMAPK1 | |
| SCHEMBL3379802 | 0.70 | BCAT2 (0.49) | ALDH1A1HSD17B10L3MBTL1HPGDMAPK1 | |
| SCHEMBL31226904 | 0.70 | BCAT2 (0.49) | ALDH1A1HSD17B10L3MBTL1HPGDMAPK1 | |
| SCHEMBL6629448 | 0.70 | SIRT1 (0.57) | SIRT1ALDH1A1HSD17B10HPGDMAPK1 | |
| SCHEMBL6647601 | 0.70 | SIRT1 (0.53) | SIRT1ALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL1030659 | 0.70 | SIRT1 (1.00) | SIRT1ALDH1A1HSD17B10L3MBTL1HPGD | |
| SCHEMBL14891741 | 0.69 | FLT3 (0.47) | ALDH1A1HSD17B10L3MBTL1MAPK1FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480977-A2 | SUBSTITUTED ARYL COMPOUNDS FOR TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003070728-A2 | AZABICYCLO-SUBSTITUTED BENZOYLAMIDES AND THIOAMIDES FOR TREATMENT OF CNS-RELATED DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2003-08-28 | — | — | WO | disclosed |