Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5182727 | 0.77 | TP53 (0.47) | KMT2AMEN1NPSR1MAPTTDP1 | |
| SCHEMBL16759779 | 0.76 | JMJD6 (0.43) | KMT2AMEN1NPSR1MAPTTDP1 | |
| SCHEMBL23217732 | 0.75 | CYP1A2 (0.46) | KMT2AMAPTCYP2C19L3MBTL1ALDH1A1 | |
| SCHEMBL8506243 | 0.73 | TDP1 (0.52) | KMT2AMEN1NPSR1MAPTTDP1 | |
| SCHEMBL19847173 | 0.73 | P2RX3 (0.38) | KMT2AMEN1NPSR1MAPTTP53 | |
| SCHEMBL4478567 | 0.72 | MAPK10 (0.60) | KMT2AMEN1MAPTCYP2C19ALDH1A1 | |
| SCHEMBL16672341 | 0.72 | PTGS2 (0.56) | KMT2AMEN1MAPTTDP1CYP2C19 | |
| SCHEMBL5183197 | 0.72 | TP53 (0.52) | KMT2AMEN1NPSR1MAPTTDP1 | |
| SCHEMBL14404822 | 0.71 | MAPT (0.67) | KMT2AMEN1NPSR1MAPTTDP1 | |
| SCHEMBL18584696 | 0.71 | BRD4 (0.49) | MAPTALDH1A1MMP2MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | Pharmacia Corporation (US) | 2004-12-29 | — | — | EP | claimed |
| WO-2003068230-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORPORATION (US) | 2003-08-21 | — | — | WO | claimed |