Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738582 | 1.00 | MEN1 (0.58) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL4684022 | 0.95 | KMT2A (0.63) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL4682172 | 0.89 | MAPT (0.56) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL4679847 | 0.87 | KMT2A (0.60) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL4683858 | 0.86 | ALDH1A1 (0.50) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL4679575 | 0.84 | KCNJ11 (0.53) | MEN1KMT2ALMNAMAPTRAB9A | |
| SCHEMBL4682188 | 0.84 | ALDH1A1 (0.48) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL4683495 | 0.84 | MAPT (0.51) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL4683467 | 0.83 | ALDH1A1 (0.55) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL4679775 | 0.82 | LMNA (0.53) | MEN1KMT2ALMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |