Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 7/20 | 0.33 |
| ▸ | CNR2 | P34972 | 3/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044717 | 0.83 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL6645262 | 0.82 | CRHR1 (0.31) | CRHR1 | |
| SCHEMBL5039357 | 0.77 | CRHR1 (0.38) | CRHR1CNR2CNR1 | |
| SCHEMBL5039336 | 0.76 | CRHR1 (0.42) | CRHR1CNR2CNR1 | |
| SCHEMBL5048476 | 0.76 | CRHR1 (0.38) | CRHR1CNR2CNR1 | |
| SCHEMBL14049584 | 0.75 | CRHR1 (0.33) | CRHR1CNR2CNR1 | |
| SCHEMBL5043567 | 0.75 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL5039224 | 0.74 | CRHR1 (0.37) | CRHR1CNR2CNR1 | |
| SCHEMBL5048463 | 0.74 | LMNA (0.38) | CRHR1CNR2CNR1 | |
| SCHEMBL5044216 | 0.74 | CNR2 (0.38) | CRHR1CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453832-A1 | RING FUSED PYRAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003048160-A1 | RING FUSED PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-12 | — | — | WO | disclosed |