SCHEMBL6650552

SCHEMBL6650552

CC(=O)n1c(=O)oc2cc(F)ccc21

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ASAH1 Q13510 11/20 0.51
IDO1 P14902 2/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
LMNA P02545 2/20 0.40
PKM P14618 2/20 0.40
CBX7 O95931 1/20 0.40
CDYL2 Q8N8U2 1/20 0.40
CDYL Q9Y232 1/20 0.40
CDY1; CDY1B Q9Y6F8 1/20 0.40
TP53 P04637 1/20 0.40
SLC6A2 P23975 1/20 0.39
HTR2A P28223 1/20 0.39
SLC6A4 P31645 1/20 0.39
SLC6A3 Q01959 1/20 0.39
HSD17B10 Q99714 1/20 0.39
ALDH1A1 P00352 1/20 0.38
GAA P10253 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10165252 0.82 ASAH1 (0.52) ASAH1IDO1MEN1KMT2ALMNA
SCHEMBL2895008 0.82 KDM4E (0.43) ASAH1IDO1MEN1KMT2ALMNA
SCHEMBL13318871 0.78 MIF (0.43) ASAH1IDO1KMT2ALMNAPKM
SCHEMBL4874614 0.77 IDO1 (0.37) ASAH1IDO1KMT2ALMNAPKM
SCHEMBL5539787 0.76 MEN1 (0.59) MEN1KMT2ALMNAPKMTP53
SCHEMBL7525629 0.76 IDO1 (0.65) ASAH1IDO1HSD17B10ALDH1A1GAA
SCHEMBL5171250 0.73 ALDH1A1 (0.50) ASAH1IDO1LMNAPKMTP53
SCHEMBL5539784 0.73 CD74 (0.42) ASAH1IDO1MEN1KMT2ALMNA
SCHEMBL3047009 0.72 CD74 (0.49) ASAH1IDO1MEN1KMT2APKM
SCHEMBL13962146 0.72 GPR55 (0.42) ASAH1IDO1MEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1087952-B1 BENZAZOLE COMPOUNDS AND THEIR USE NOVARTIS AG (CH) 2004-06-02 EP claimed
US-6410578-B1 INSECTICIDE, MITICIES, PESTICIDE NOVARTIS ANIMAL HEALTH US, INC. 2002-06-25 US claimed
CN-1302293-A Benzazole compounds and their use NOVARTIS AG (CH) 2001-07-04 CN claimed
EP-1087952-A1 BENZAZOLE COMPOUNDS AND THEIR USE Novartis AG (CH) 2001-04-04 EP claimed
WO-1999065886-A1 BENZAZOLE COMPOUNDS AND THEIR USE NOVARTIS AG (CH) 1999-12-23 WO claimed
EP-1087952-B1 BENZAZOLE COMPOUNDS AND THEIR USE NOVARTIS AG (CH) 2004-06-02 EP disclosed
US-6410578-B1 INSECTICIDE, MITICIES, PESTICIDE NOVARTIS ANIMAL HEALTH US, INC. 2002-06-25 US disclosed
CN-1302293-A Benzazole compounds and their use NOVARTIS AG (CH) 2001-07-04 CN disclosed
EP-1087952-A1 BENZAZOLE COMPOUNDS AND THEIR USE Novartis AG (CH) 2001-04-04 EP disclosed
WO-1999065886-A1 BENZAZOLE COMPOUNDS AND THEIR USE NOVARTIS AG (CH) 1999-12-23 WO disclosed