Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 4/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.38 |
| ▸ | CDC7 | O00311 | 5/20 | 0.37 |
| ▸ | DBF4 | Q9UBU7 | 5/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | WRN | Q14191 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5339268 | 0.92 | CDK5 (0.40) | CDK5CDK5R1CDC7DBF4POLB | |
| Hydrochloric Acid SCHEMBL5354413 | 0.91 | CDK5 (0.40) | CDK5CDK5R1CDC7DBF4POLB | |
| SCHEMBL5338097 | 0.80 | RAB9A (0.55) | CDK5CDK5R1POLBMAPTALDH1A1 | |
| SCHEMBL5341200 | 0.74 | CDK5 (0.60) | CDK5CDK5R1BLMHPGDDYRK1A | |
| SCHEMBL6629791 | 0.74 | CDK5 (0.54) | CDK5CDK5R1PRKCAHPGDDYRK1A | |
| SCHEMBL5354931 | 0.73 | CDK5 (0.58) | CDK5CDK5R1BLMHPGDDYRK1A | |
| SCHEMBL14558329 | 0.72 | CDK5 (0.62) | CDK5CDK5R1BLMHPGDDYRK1A | |
| SCHEMBL5689495 | 0.69 | CDK5 (0.65) | CDK5CDK5R1BLMHPGDDYRK1A | |
| SCHEMBL5347914 | 0.68 | CDK5 (0.46) | CDK5CDK5R1PRKCAPOLBMAPT | |
| SCHEMBL5343066 | 0.68 | CDK5 (0.51) | CDK5CDK5R1BLMHPGDDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483263-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003070727-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-08-28 | — | — | WO | disclosed |