Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5113417 | 0.99 | TP53 (0.35) | TP53NPC1S1PR4LMNAMAPT | |
| SCHEMBL5106321 | 0.89 | TP53 (0.34) | TP53NPC1S1PR4LMNAMAPT | |
| SCHEMBL5105876 | 0.81 | TP53 (0.34) | TP53 | |
| SCHEMBL5498704 | 0.72 | TP53 (0.36) | TP53MAPT | |
| SCHEMBL5112642 | 0.71 | ALDH1A1 (0.43) | TP53S1PR4HPGD | |
| SCHEMBL5139368 | 0.70 | TP53 (0.33) | TP53 | |
| SCHEMBL5487155 | 0.70 | TP53 (0.38) | TP53 | |
| SCHEMBL5113296 | 0.68 | TP53 (0.36) | TP53LMNA | |
| SCHEMBL5492086 | 0.65 | TP53 (0.36) | TP53 | |
| SCHEMBL5099902 | 0.63 | CRHR1 (0.55) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383498-A1 | CRF RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002087573-A1 | CRF RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2002-11-07 | — | — | WO | disclosed |