Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801566 | 0.80 | SLC6A2 (0.48) | EPHX1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL3289195 | 0.79 | EPHX1 (0.48) | EPHX1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL30846601 | 0.79 | EPHX1 (0.48) | EPHX1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL30846613 | 0.79 | EPHX1 (0.48) | EPHX1SLC6A2TAAR1MAOASLC6A4 | |
| Hydrochloric Acid SCHEMBL8800673 | 0.79 | SLC6A2 (0.47) | EPHX1SLC6A2TAAR1MAOASLC6A4 | |
| Hydrochloric Acid SCHEMBL9482622 | 0.77 | EPHX1 (0.47) | EPHX1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL3906596 | 0.73 | SLC5A2 (0.52) | EPHX1SLC5A2 | |
| SCHEMBL6570901 | 0.72 | ALDH1A1 (0.40) | EPHX1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL6645769 | 0.71 | SLC6A2 (0.58) | EPHX1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL24017042 | 0.71 | EPHX1 (0.70) | EPHX1SLC6A2TAAR1MAOASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478645-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | Amgen Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003066630-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | AMGEN INC. (US) | 2003-08-14 | — | — | WO | disclosed |