Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | EIF4E | P06730 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.39 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | MPL | P40238 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6627147 | 0.82 | KDM4E (0.55) | KDM4EARCYP19A1RAB9ANPC1 | |
| SCHEMBL6648183 | 0.81 | CACNA1B (0.39) | SCN9AEIF4EKDM4EARCYP19A1 | |
| SCHEMBL6654412 | 0.77 | KDM4E (0.55) | KDM4EARCYP19A1RAB9ASMN1; SMN2 | |
| SCHEMBL6627829 | 0.77 | KDM4E (0.59) | KDM4EARCYP19A1RAB9ASMN1; SMN2 | |
| SCHEMBL6649714 | 0.77 | CYP19A1 (0.43) | SCN9AALOX5EIF4EKDM4EAR | |
| SCHEMBL6649359 | 0.77 | CYP19A1 (0.46) | SCN9AALOX5EIF4EKDM4EAR | |
| SCHEMBL6649722 | 0.76 | SREBF2 (0.46) | SCN9AALOX5EIF4EKDM4EAR | |
| SCHEMBL6649421 | 0.76 | KDM4E (0.50) | SCN9AKDM4EARCYP19A1RAB9A | |
| SCHEMBL6651514 | 0.74 | RAB9A (0.46) | SCN9AKDM4EARCYP19A1RAB9A | |
| SCHEMBL6649186 | 0.74 | RAB9A (0.57) | EIF4EKDM4ERAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432706-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027085-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |