Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | AR | P10275 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 10/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6627147 | 0.92 | KDM4E (0.55) | KDM4EKMT2AARRAB9AALDH1A1 | |
| SCHEMBL6627829 | 0.87 | KDM4E (0.59) | KDM4EKMT2AARRAB9AALDH1A1 | |
| SCHEMBL6651312 | 0.82 | CYP19A1 (0.42) | KDM4EKMT2AARRAB9AALDH1A1 | |
| SCHEMBL6651514 | 0.79 | RAB9A (0.46) | KDM4EKMT2AARRAB9AALDH1A1 | |
| SCHEMBL6649421 | 0.79 | KDM4E (0.50) | KDM4EKMT2AARRAB9AALDH1A1 | |
| SCHEMBL6653028 | 0.79 | MAPT (0.50) | KMT2ARAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL6648628 | 0.79 | CYP19A1 (0.60) | KDM4EKMT2AARRAB9AALDH1A1 | |
| SCHEMBL6651242 | 0.77 | SCN9A (0.42) | KDM4EARRAB9ACYP19A1NPC1 | |
| SCHEMBL6649842 | 0.77 | CYP19A1 (0.52) | KDM4EKMT2ARAB9AALDH1A1CYP19A1 | |
| SCHEMBL6648655 | 0.76 | KDM4E (0.71) | KDM4EKMT2AARRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432706-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027085-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |