Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 11/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6627829 | 0.82 | KDM4E (0.59) | CYP19A1KDM4ERAB9ANPC1ALDH1A1 | |
| SCHEMBL6654412 | 0.82 | KDM4E (0.55) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL6627147 | 0.80 | KDM4E (0.55) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL6651298 | 0.75 | CYP19A1 (0.47) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL6648609 | 0.75 | CYP19A1 (0.44) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL6648612 | 0.74 | CYP19A1 (0.43) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL6649421 | 0.74 | KDM4E (0.50) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL6651514 | 0.74 | RAB9A (0.46) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL6648183 | 0.74 | CACNA1B (0.39) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL6653028 | 0.74 | MAPT (0.50) | RAB9ANPC1ALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432706-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027085-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |