Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | EIF4E | P06730 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 9/20 | 0.47 |
| ▸ | MAOB | P27338 | 9/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | VCP | P55072 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6649515 | 0.96 | MAPT (0.51) | MAPTEIF4EMAOAMAOBCSNK2A1 | |
| SCHEMBL6648546 | 0.81 | MAOA (0.52) | MAPTEIF4EMAOAMAOBCSNK2A1 | |
| SCHEMBL6646928 | 0.80 | MAPT (0.48) | MAPTEIF4EMAOAMAOBCSNK2A1 | |
| SCHEMBL6804280 | 0.80 | CYP19A1 (0.68) | MAPTRAB9AALDH1A1GAANPC1 | |
| SCHEMBL7253741 | 0.80 | KDM4E (0.44) | MAPTRAB9AGAANPC1LMNA | |
| SCHEMBL6646934 | 0.79 | MAOA (0.50) | MAPTEIF4EMAOAMAOBCSNK2A1 | |
| Bromide SCHEMBL7079674 | 0.79 | CYP19A1 (0.66) | MAPTRAB9AALDH1A1MEN1GAA | |
| SCHEMBL6654412 | 0.79 | KDM4E (0.55) | MAPTRAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL6651017 | 0.78 | C1S (0.47) | MAPTEIF4EALDH1A1MEN1KMT2A | |
| SCHEMBL6649421 | 0.78 | KDM4E (0.50) | MAPTRAB9AALDH1A1MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432706-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027085-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |