Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD1 | P21728 | 3/20 | 0.39 |
| ▸ | DRD5 | P21918 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29051650 | 0.85 | HTR2C (0.53) | HTR2CHTR2AHTR2BADRA2AKDM1A | |
| SCHEMBL1904887 | 0.82 | HTR2C (0.48) | HTR2CHTR2AHTR2BADRA2AKDM1A | |
| SCHEMBL30468465 | 0.81 | ADRA2A (0.49) | HTR2CHTR2AHTR2BADRA2AKDM1A | |
| SCHEMBL15194128 | 0.80 | ADRA2A (0.64) | HTR2CHTR2AADRA2A | |
| SCHEMBL15194127 | 0.80 | ADRA2A (0.64) | HTR2CHTR2AADRA2A | |
| SCHEMBL6655706 | 0.76 | HTR2C (0.48) | HTR2CHTR2AHTR2BADRA2AKDM1A | |
| SCHEMBL173319 | 0.76 | HTR2A (0.51) | HTR2CHTR2AHTR2BKDM1ADRD2 | |
| SCHEMBL225918 | 0.76 | HTR2C (0.60) | HTR2CHTR2AHTR2BADRA2ADRD2 | |
| SCHEMBL31317936 | 0.76 | HTR2C (0.60) | HTR2CHTR2AHTR2BADRA2ADRD2 | |
| SCHEMBL22145508 | 0.75 | KDM1A (0.46) | HTR2CHTR2AHTR2BADRA2AKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411881-A4 | 5HT sb 2C /sb RECEPTOR MODULATORS | ARENA PHARM INC (US) | 2004-07-07 | — | — | EP | disclosed |
| EP-1411881-A2 | 5HT sb 2C /sb RECEPTOR MODULATORS | Arena Pharmaceuticals, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003086306-A2 | 5HT2C RECEPTOR MODULATORS | ARENA PHARMACEUTICALS, INC. (US) | 2003-10-23 | — | — | WO | disclosed |