Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.48 |
| ▸ | HTR2B | P41595 | 4/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29051650 | 0.79 | HTR2C (0.53) | HTR2CHTR2BHTR2AADRA2AKDM1A | |
| SCHEMBL30468465 | 0.77 | ADRA2A (0.49) | HTR2CHTR2BHTR2AADRA2AKDM1A | |
| SCHEMBL1904887 | 0.76 | HTR2C (0.48) | HTR2CHTR2BHTR2AADRA2AKDM1A | |
| SCHEMBL6651372 | 0.76 | HTR2C (0.48) | HTR2CHTR2BHTR2AADRA2AKDM1A | |
| SCHEMBL25438091 | 0.73 | KDM1A (0.43) | HTR2CHTR2BHTR2AADRA2AKDM1A | |
| SCHEMBL225918 | 0.72 | HTR2C (0.60) | HTR2CHTR2BHTR2AADRA2AADRA2B | |
| SCHEMBL31317936 | 0.72 | HTR2C (0.60) | HTR2CHTR2BHTR2AADRA2AADRA2B | |
| SCHEMBL16694747 | 0.72 | KDM1A (0.41) | HTR2CHTR2BHTR2AADRA2AKDM1A | |
| SCHEMBL2501566 | 0.71 | KDM1A (0.52) | HTR2CHTR2BHTR2AADRA2AKDM1A | |
| Hydrochloric Acid SCHEMBL3694891 | 0.71 | HTR2C (0.58) | HTR2CHTR2BHTR2AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411881-A4 | 5HT sb 2C /sb RECEPTOR MODULATORS | ARENA PHARM INC (US) | 2004-07-07 | — | — | EP | disclosed |
| EP-1411881-A2 | 5HT sb 2C /sb RECEPTOR MODULATORS | Arena Pharmaceuticals, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003086306-A2 | 5HT2C RECEPTOR MODULATORS | ARENA PHARMACEUTICALS, INC. (US) | 2003-10-23 | — | — | WO | disclosed |