Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 13/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6653472 | 0.95 | P2RX7 (0.45) | P2RX7LMNAALDH1A1P2RX3KDM4E | |
| SCHEMBL6655639 | 0.91 | P2RX7 (0.45) | P2RX7LMNAALDH1A1POLBHTT | |
| Hydrochloric Acid SCHEMBL6674326 | 0.88 | P2RX7 (0.60) | P2RX7LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL6647801 | 0.86 | P2RX7 (0.52) | P2RX7LMNAALDH1A1EPHX2CNR1 | |
| SCHEMBL6651560 | 0.81 | P2RX7 (0.43) | P2RX7LMNASMN1; SMN2 | |
| SCHEMBL6694983 | 0.81 | P2RX7 (0.43) | P2RX7 | |
| SCHEMBL6653481 | 0.81 | P2RX7 (0.45) | P2RX7LMNAALDH1A1 | |
| SCHEMBL6655499 | 0.80 | P2RX7 (0.42) | P2RX7LMNAKDM4EMAPTEPHX2 | |
| SCHEMBL6686286 | 0.80 | P2RX7 (0.43) | P2RX7KDM4EEPHX2 | |
| SCHEMBL6658009 | 0.79 | P2RX7 (0.42) | P2RX7KDM4EMAPTEPHX2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490341-A1 | NOVEL ADAMANTANE DERIVATIVES | AstraZeneca AB (SE) | 2004-12-29 | — | — | EP | claimed |
| WO-2003080579-A1 | NOVEL ADAMANTANE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-10-02 | — | — | WO | claimed |
| EP-1490341-A1 | NOVEL ADAMANTANE DERIVATIVES | AstraZeneca AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003080579-A1 | NOVEL ADAMANTANE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-10-02 | — | — | WO | disclosed |