Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | VCP | P55072 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6686286 | 0.91 | P2RX7 (0.43) | P2RX7KDM4EMEN1KMT2AEPHX2 | |
| SCHEMBL6694983 | 0.91 | P2RX7 (0.43) | P2RX7MEN1KMT2AAURKARPS6KB1 | |
| SCHEMBL6651560 | 0.85 | P2RX7 (0.43) | P2RX7MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6653472 | 0.84 | P2RX7 (0.45) | P2RX7KDM4EMAPTEPHX2 | |
| SCHEMBL6655499 | 0.83 | P2RX7 (0.42) | P2RX7KDM4EAURKARPS6KB1MAPT | |
| SCHEMBL6653481 | 0.82 | P2RX7 (0.45) | P2RX7 | |
| SCHEMBL6647801 | 0.81 | P2RX7 (0.52) | P2RX7EPHX2 | |
| Hydrochloric Acid SCHEMBL6674326 | 0.80 | P2RX7 (0.60) | P2RX7KDM4EMAPT | |
| SCHEMBL6651900 | 0.79 | P2RX7 (0.47) | P2RX7KDM4ESMN1; SMN2MAPTEPHX2 | |
| SCHEMBL4506903 | 0.78 | P2RX7 (0.71) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490341-A1 | NOVEL ADAMANTANE DERIVATIVES | AstraZeneca AB (SE) | 2004-12-29 | — | — | EP | claimed |
| WO-2003080579-A1 | NOVEL ADAMANTANE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-10-02 | — | — | WO | claimed |