Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | DPYD | Q12882 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | DAO | P14920 | 3/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6652195 | 0.89 | MAPK14 (0.38) | MAPK14DPYDMAOBDAOGAA | |
| SCHEMBL6648037 | 0.88 | THRA (0.41) | DPYDMAOBDAOPDE3BPDE3A | |
| SCHEMBL4379215 | 0.82 | MAPT (0.41) | MAPK14DPYDMAOBDAOGAA | |
| SCHEMBL6832447 | 0.82 | FFAR1 (0.41) | MAOBDAOGAAL3MBTL1MAPT | |
| SCHEMBL6650193 | 0.79 | DAO (0.43) | MAPK14DAOPDE3BPDE3AMAPT | |
| SCHEMBL6471595 | 0.78 | DAO (0.39) | DPYDDAOPDE3BPDE3A | |
| SCHEMBL6471736 | 0.77 | MAPK14 (0.42) | MAPK14MAOB | |
| SCHEMBL6471484 | 0.77 | DPYD (0.46) | MAPK14DPYDGAAMAPTKMT2A | |
| SCHEMBL6647299 | 0.77 | DAO (0.52) | DAOPDE3BPDE3A | |
| SCHEMBL6472836 | 0.76 | NR4A1 (0.47) | DPYDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | Pharmacia Corporation (US) | 2004-12-29 | — | — | EP | claimed |
| WO-2003068230-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORPORATION (US) | 2003-08-21 | — | — | WO | claimed |
| EP-1490064-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | Pharmacia Corporation (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003068230-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORPORATION (US) | 2003-08-21 | — | — | WO | disclosed |