Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6652195 | 0.87 | MAPK14 (0.38) | MAPTKMT2AALDH1A1PKML3MBTL1 | |
| SCHEMBL6652310 | 0.82 | MAPK14 (0.47) | MAPTKMT2AL3MBTL1GAAMAOB | |
| SCHEMBL6832447 | 0.80 | FFAR1 (0.41) | MAPTKMT2AALDH1A1L3MBTL1GAA | |
| SCHEMBL6471640 | 0.79 | DPYD (0.41) | MAPTKMT2AALDH1A1L3MBTL1GAA | |
| SCHEMBL6472836 | 0.76 | NR4A1 (0.47) | KMT2ASMN1; SMN2HDAC1HDAC6PTGER1 | |
| SCHEMBL6652475 | 0.76 | DPYD (0.41) | ALDH1A1SMN1; SMN2HDAC1HDAC6PTGER1 | |
| SCHEMBL6473794 | 0.75 | SIRT2 (0.40) | KMT2AALDH1A1SMN1; SMN2DPYD | |
| SCHEMBL6472151 | 0.74 | PARP10 (0.49) | MAOBHDAC1HDAC6DPYD | |
| SCHEMBL6472862 | 0.74 | IMPDH2 (0.40) | MAPTALDH1A1GAASMN1; SMN2MAOB | |
| SCHEMBL6471088 | 0.73 | THRA (0.45) | ALDH1A1L3MBTL1SMN1; SMN2LMNAPTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |