Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9755385 | 0.84 | ALDH1A1 (0.47) | ALDH1A1HPGDGLAKDM4EGAA | |
| SCHEMBL29202173 | 0.82 | ALDH1A1 (0.55) | ALDH1A1HPGDGLAKDM4EGAA | |
| SCHEMBL29387399 | 0.82 | APAF1 (0.49) | ALDH1A1KDM4EKMT2AAPAF1CASP3 | |
| SCHEMBL2185816 | 0.82 | APAF1 (0.49) | ALDH1A1KDM4EKMT2AAPAF1CASP3 | |
| SCHEMBL5348096 | 0.80 | CRHR1 (0.50) | ALDH1A1HPGDGLAKDM4EGAA | |
| SCHEMBL93696 | 0.79 | ALDH1A1 (0.51) | ALDH1A1HPGDGLAKDM4EGAA | |
| SCHEMBL2872359 | 0.78 | KDM4E (0.55) | ALDH1A1HPGDGLAKDM4EGAA | |
| SCHEMBL14188176 | 0.78 | APAF1 (0.46) | ALDH1A1KDM4EKMT2AAPAF1CASP3 | |
| Hydrochloric Acid SCHEMBL8003436 | 0.77 | ALDH1A1 (0.53) | ALDH1A1HPGDGLAKDM4EGAA | |
| Bromide SCHEMBL8003449 | 0.77 | KDM4E (0.53) | ALDH1A1HPGDGLAKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478645-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | Amgen Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003066630-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | AMGEN INC. (US) | 2003-08-14 | — | — | WO | disclosed |