Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | DHODH | Q02127 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | LDHB | P07195 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9898347 | 0.78 | DHODH (0.50) | KDM4EALDH1A1GAADHODHHSD17B10 | |
| SCHEMBL28261472 | 0.78 | KDM4E (0.50) | KDM4EALDH1A1GAADHODHHSD17B10 | |
| SCHEMBL28261476 | 0.75 | KDM4E (0.50) | KDM4EALDH1A1GAADHODHHSD17B10 | |
| SCHEMBL6652410 | 0.75 | KDM4E (0.52) | KDM4EALDH1A1GAAPOLBHSD17B10 | |
| SCHEMBL7815882 | 0.75 | KDM4E (0.50) | KDM4EALDH1A1GAADHODHPOLB | |
| SCHEMBL5160775 | 0.74 | PDE10A (0.49) | KDM4EALDH1A1DHODHHSD17B10HPGD | |
| SCHEMBL6273226 | 0.73 | ALDH1A1 (0.50) | KDM4EALDH1A1GAAPOLBHSD17B10 | |
| SCHEMBL11869454 | 0.73 | DHODH (0.63) | KDM4EALDH1A1GAADHODHPOLB | |
| SCHEMBL7456021 | 0.71 | KDM4E (0.58) | KDM4EALDH1A1GAADHODHPOLB | |
| SCHEMBL14192902 | 0.71 | KDM4E (0.52) | KDM4EALDH1A1GAAPOLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835870-B1 | Photochromic substituted naphthopyrans | PPG IND OHIO INC (US) | 2004-03-03 | — | — | EP | disclosed |
| EP-0835870-A1 | Photochromic substituted naphthopyrans | PPG INDUSTRIES, INC. (US) | 1998-04-15 | — | — | EP | disclosed |
| US-5573712-A | PHOTOCHROMIC ARTICLE COMPRISING ORGANIC HOST AND THE PHOTOCHROMIC NAPHTHOPYRAN | TRANSITIONS OPTICAL, INC. (US) | 1996-11-12 | — | — | US | disclosed |
| US-5458814-A | Ophthalmic lenses | TRANSITIONS OPTICAL, INC. (US) | 1995-10-17 | — | — | US | disclosed |