SCHEMBL5160775

SCHEMBL5160775

Cc1c(C(=O)O)c(C)c2ccccc2c1O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 3/20 0.49
TSHR P16473 2/20 0.45
HPGD P15428 3/20 0.44
HSD17B10 Q99714 3/20 0.44
CYP2C9 P11712 2/20 0.44
THRB P10828 1/20 0.44
ALOX12 P18054 1/20 0.44
ATIC P31939 1/20 0.44
KDM4E B2RXH2 4/20 0.44
KMT2A Q03164 4/20 0.44
MEN1 O00255 2/20 0.44
ALDH1A1 P00352 2/20 0.44
CYP1A2 P05177 1/20 0.44
GLA P06280 1/20 0.44
CYP2C19 P33261 1/20 0.44
LDHA P00338 3/20 0.43
LDHB P07195 3/20 0.43
DHODH Q02127 3/20 0.42
HTT P42858 2/20 0.42
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5162563 0.90 PDE10A (0.50) PDE10ATSHRHPGDHSD17B10CYP2C9
SCHEMBL6171244 0.88 PDE10A (0.49) PDE10ATSHRHPGDHSD17B10CYP2C9
SCHEMBL655431 0.85 PDE10A (0.57) PDE10ATSHRHPGDHSD17B10KDM4E
SCHEMBL8074031 0.84 LDHA (0.51) PDE10ATSHRHPGDHSD17B10CYP2C9
SCHEMBL19203141 0.84 LDHA (0.49) PDE10ATSHRHPGDHSD17B10CYP2C9
SCHEMBL30706629 0.84 LDHA (0.49) PDE10ATSHRHPGDHSD17B10CYP2C9
SCHEMBL31520079 0.84 LDHA (0.51) PDE10ATSHRHPGDHSD17B10CYP2C9
SCHEMBL340400 0.80 LDHA (0.51) PDE10ATSHRHPGDHSD17B10CYP2C9
SCHEMBL19203138 0.80 LDHA (0.66) PDE10ATSHRHPGDHSD17B10CYP2C9
SCHEMBL15013474 0.79 DHODH (0.54) PDE10ATSHRDHODHMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1000025-B1 SUBSTITUTED NAPHTHOPYRANS TRANSITIONS OPTICAL INC (US) 2007-02-21 EP disclosed
EP-1000025-A4 SUBSTITUTED NAPHTHOPYRANS TRANSITIONS OPTICAL INC (US) 2002-10-09 EP disclosed
EP-1000025-A1 SUBSTITUTED NAPHTHOPYRANS TRANSITIONS OPTICAL, INC. (US) 2000-05-17 EP disclosed
WO-1998055457-A1 SUBSTITUTED NAPHTHOPYRANS TRANSITIONS OPTICAL, INC. (US) 1998-12-10 WO disclosed
US-5658500-A REVERSIBLE PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 1997-08-19 US disclosed