SCHEMBL6652862

SCHEMBL6652862

S=Cc1ccc(Oc2ccc(Cl)cc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.52
MAOB P27338 1/20 0.52
ELANE P08246 2/20 0.41
HSD17B10 Q99714 1/20 0.41
LTA4H P09960 5/20 0.39
ALDH1A1 P00352 3/20 0.38
HPGD P15428 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2D6 P10635 1/20 0.38
MAPT P10636 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
KMT2A Q03164 1/20 0.38
LMNA P02545 1/20 0.38
SCN9A Q15858 1/20 0.38
HAO1 Q9UJM8 1/20 0.37
ALOX5 P09917 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3081358 0.85
SCHEMBL457634 0.80 MAOA (0.74) MAOAMAOBLTA4HALDH1A1HPGD
SCHEMBL9242729 0.80 MAOA (0.74) MAOAMAOBLTA4HALDH1A1HPGD
SCHEMBL7040563 0.77 MAOB (0.52) MAOAMAOBELANEHSD17B10LTA4H
SCHEMBL2267829 0.77 HSD17B10 (0.73) MAOAMAOBELANEHSD17B10ALDH1A1
SCHEMBL30385926 0.77 MAOA (0.70) MAOAMAOBLTA4HALDH1A1HPGD
SCHEMBL6159475 0.72 HTT (0.57) MAOAMAOBALDH1A1SMN1; SMN2MEN1
SCHEMBL7479567 0.72 MAOA (0.47) MAOAMAOBALDH1A1SMN1; SMN2CYP2C9
SCHEMBL4180058 0.72 MAOA (0.47) MAOAMAOBELANEHSD17B10LTA4H
SCHEMBL16945360 0.72 HTT (0.57) MAOAMAOBALDH1A1SMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140813-B1 METHOD FOR PREPARING AROMATIC DIPHENYL THIOETHERS RHODIA CHIMIE SA (FR) 2004-06-16 EP claimed
US-6596905-B1 Reacting diazonium salt of aromatic diphenyl compound with organic disulfide in presence of coupling catalyst RHODIA CHIMIE (FR) 2003-07-22 US claimed
EP-1140813-A1 METHOD FOR PREPARING AROMATIC DIPHENYL THIOETHERS RHODIA CHIMIE (FR) 2001-10-10 EP claimed
WO-2000039079-A1 METHOD FOR PREPARING AROMATIC DIPHENYL THIOETHERS RHODIA CHIMIE (FR) 2000-07-06 WO claimed
EP-1140813-B1 METHOD FOR PREPARING AROMATIC DIPHENYL THIOETHERS RHODIA CHIMIE SA (FR) 2004-06-16 EP disclosed
EP-1140813-B1 METHOD FOR PREPARING AROMATIC DIPHENYL THIOETHERS RHODIA CHIMIE SA (FR) 2004-06-16 EP disclosed
US-6596905-B1 Reacting diazonium salt of aromatic diphenyl compound with organic disulfide in presence of coupling catalyst RHODIA CHIMIE (FR) 2003-07-22 US disclosed
US-6596905-B1 Reacting diazonium salt of aromatic diphenyl compound with organic disulfide in presence of coupling catalyst RHODIA CHIMIE (FR) 2003-07-22 US disclosed
CN-1331676-A Process for the preparation of aromatic thioethers of the diphenyl type RHODIA CHIMIE SA (FR) 2002-01-16 CN disclosed
EP-1140813-A1 METHOD FOR PREPARING AROMATIC DIPHENYL THIOETHERS RHODIA CHIMIE (FR) 2001-10-10 EP disclosed
EP-1140813-A1 METHOD FOR PREPARING AROMATIC DIPHENYL THIOETHERS RHODIA CHIMIE (FR) 2001-10-10 EP disclosed
WO-2000039079-A1 METHOD FOR PREPARING AROMATIC DIPHENYL THIOETHERS RHODIA CHIMIE (FR) 2000-07-06 WO disclosed
WO-2000039079-A1 METHOD FOR PREPARING AROMATIC DIPHENYL THIOETHERS RHODIA CHIMIE (FR) 2000-07-06 WO disclosed