Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 14/20 | 0.49 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.48 |
| ▸ | MIF | P14174 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27837540 | 0.85 | P4HTM (0.52) | P4HTMP4HA1MIFKDM4EALDH1A1 | |
| SCHEMBL6650658 | 0.84 | KMT2A (0.45) | P4HTMKMT2ALMNAMAPTTSHR | |
| SCHEMBL6920475 | 0.83 | P4HTM (0.53) | P4HTMP4HA1MIFKDM4EALDH1A1 | |
| SCHEMBL30181544 | 0.83 | P4HTM (0.53) | P4HTMP4HA1MIFKDM4EALDH1A1 | |
| SCHEMBL6651599 | 0.81 | PIK3CD (0.41) | P4HTMMAPT | |
| SCHEMBL29571426 | 0.81 | MAPK1 (0.56) | KDM4EALDH1A1L3MBTL1MAPK1LMNA | |
| SCHEMBL6650491 | 0.81 | MAPK1 (0.56) | KDM4EALDH1A1L3MBTL1MAPK1LMNA | |
| SCHEMBL6649788 | 0.81 | MAPT (0.41) | KDM4EALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL14358092 | 0.80 | KDM4E (0.53) | P4HTMP4HA1MIFKDM4EALDH1A1 | |
| SCHEMBL25523204 | 0.80 | P4HTM (0.50) | P4HTMP4HA1MIFKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0926137-B1 | Picolin acid derivatives useful in the treatment of IL-1 and TNF mediated diseases | PFIZER (US) | 2004-05-12 | — | — | EP | disclosed |
| US-6416979-B1 | MARASMIELLUS CULTURE PRODUCT; ANTIINFLAMMATORY AGENT, ANTIARTHRITIC AGENTS | PFIZER INC. | 2002-07-09 | — | — | US | disclosed |
| US-6194442-B1 | ANTIINFLAMMATORY AGENT | PFIZER INC | 2001-02-27 | — | — | US | disclosed |
| US-6034107-A | RHEUMATIC DISORDERS, ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 2000-03-07 | — | — | US | disclosed |
| EP-0926137-A1 | Picolin acid derivatives useful in the treatment of IL-1 and TNF mediated diseases | PFIZER INC. (US) | 1999-06-30 | — | — | EP | disclosed |