Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | OGA | O60502 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12089852 | 0.85 | HSD11B1 (0.41) | PIK3CDPIK3CAPIK3CBPI4KAPIK3CG | |
| SCHEMBL7738796 | 0.83 | ALDH1A1 (0.42) | APLNRMAPTNPC1RAB9AKDM4A | |
| SCHEMBL6652918 | 0.81 | P4HTM (0.49) | MAPTP4HTM | |
| SCHEMBL6650658 | 0.80 | KMT2A (0.45) | APLNRMAPTP4HTMNPC1RAB9A | |
| SCHEMBL23561173 | 0.79 | ALDH1A1 (0.42) | PIK3CDPIK3CAPIK3CBPI4KAPIK3CG | |
| SCHEMBL24958737 | 0.79 | ALDH1A1 (0.42) | PIK3CDPIK3CAPIK3CBPI4KAPIK3CG | |
| SCHEMBL6650491 | 0.77 | MAPK1 (0.56) | DYRK1AMAPTGRM5NPC1RAB9A | |
| SCHEMBL29571426 | 0.77 | MAPK1 (0.56) | DYRK1AMAPTGRM5NPC1RAB9A | |
| SCHEMBL6649788 | 0.77 | MAPT (0.41) | PIK3CAPI4KAPI4KBMAPTGRM5 | |
| SCHEMBL1976172 | 0.72 | PIK3CD (0.43) | PIK3CDPIK3CAPIK3CBPI4KAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0926137-B1 | Picolin acid derivatives useful in the treatment of IL-1 and TNF mediated diseases | PFIZER (US) | 2004-05-12 | — | — | EP | disclosed |
| US-6416979-B1 | MARASMIELLUS CULTURE PRODUCT; ANTIINFLAMMATORY AGENT, ANTIARTHRITIC AGENTS | PFIZER INC. | 2002-07-09 | — | — | US | disclosed |
| US-6194442-B1 | ANTIINFLAMMATORY AGENT | PFIZER INC | 2001-02-27 | — | — | US | disclosed |
| US-6034107-A | RHEUMATIC DISORDERS, ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 2000-03-07 | — | — | US | disclosed |
| EP-0926137-A1 | Picolin acid derivatives useful in the treatment of IL-1 and TNF mediated diseases | PFIZER INC. (US) | 1999-06-30 | — | — | EP | disclosed |