SCHEMBL6653280

SCHEMBL6653280

Cc1[nH]c(-c2ccc(C(F)(F)F)cc2)nc1CN1CCC(N(Cc2ccccc2)C(=O)Nc2ccccc2)CC1

nearest known ligand 0.59

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
DCUN1D1 Q96GG9 15/20 0.59
UBE2M P61081 14/20 0.59
CTSS P25774 5/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7247405 0.98 UBE2M (0.57) DCUN1D1UBE2MCTSS
SCHEMBL6654703 0.97 UBE2M (0.55) DCUN1D1UBE2MCTSS
SCHEMBL6653325 0.96 UBE2M (0.55) DCUN1D1UBE2MCTSS
SCHEMBL6652066 0.96 UBE2M (0.55) DCUN1D1UBE2MCTSS
SCHEMBL6654934 0.96 UBE2M (0.55) DCUN1D1UBE2MCTSS
SCHEMBL6632673 0.95 UBE2M (0.58) DCUN1D1UBE2MCTSS
SCHEMBL6650845 0.95 UBE2M (0.53) DCUN1D1UBE2MCTSS
SCHEMBL6662286 0.95 UBE2M (0.53) DCUN1D1UBE2MCTSS
SCHEMBL6653189 0.95 UBE2M (0.53) DCUN1D1UBE2MCTSS
SCHEMBL6655425 0.95 UBE2M (0.53) DCUN1D1UBE2MCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1417202-A2 AMINOPIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY F. HOFFMANN-LA ROCHE AG (CH) 2004-05-12 EP claimed
US-20030069276-A1 Amino piperidine derivatives F.HOFFMANN-LA ROCHE AG (CH) 2003-04-10 US claimed
WO-2002079186-A2 AMINOPIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY F. HOFFMANN-LA ROCHE AG (CH) 2002-10-10 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030069276-A1 Amino piperidine derivatives CCR5, CCR2, CXCR4 DCUN1D1 3697/4885UBE2M 3824/4885CTSS 3409/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.