Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.78 |
| ▸ | MEN1 | O00255 | 6/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.78 |
| ▸ | GAA | P10253 | 5/20 | 0.78 |
| ▸ | THRB | P10828 | 3/20 | 0.78 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.78 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.78 |
| ▸ | GFER | P55789 | 2/20 | 0.55 |
| ▸ | RAD52 | P43351 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | YWHAG | P61981 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6156455 | 0.90 | ALDH1A1 (0.96) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL241271 | 0.88 | ALDH1A1 (0.93) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL7031588 | 0.86 | ALDH1A1 (0.89) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL6272228 | 0.84 | ALDH1A1 (0.86) | MAPTALDH1A1MEN1KMT2AGAA | |
| Sulfuric Acid SCHEMBL7807226 | 0.83 | KDM4E (0.57) | MAPTALDH1A1MEN1KMT2AGAA | |
| Hydrochloric Acid SCHEMBL7051020 | 0.83 | ALDH1A1 (0.89) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL15358737 | 0.82 | MAPT (0.81) | MAPTALDH1A1MEN1KMT2AGAA | |
| Sulfuric Acid SCHEMBL7811911 | 0.82 | RAB9A (0.59) | MAPTALDH1A1MEN1KMT2AGAA | |
| Sulfuric Acid SCHEMBL7811935 | 0.82 | RAB9A (0.59) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL3658575 | 0.80 | ALDH1A1 (0.55) | MAPTALDH1A1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891765-B1 | Oxidative hair dye compositions | P & G CLAIROL INC (US) | 2004-06-16 | — | — | EP | disclosed |
| EP-0891765-A2 | Oxidative hair dye compositions | Bristol-Myers Squibb Company (US) | 1999-01-20 | — | — | EP | disclosed |
| US-5851237-A | Oxidative hair dye compositions and methods containing 1--(4-aminophenyl) pyrrolidines | NOXELL CORPORATION | 1998-12-22 | — | — | US | disclosed |