Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290576 | 0.77 | ADRB1 (0.42) | KMT2AALDH1A1MEN1MAPTLMNA | |
| SCHEMBL9030269 | 0.71 | HSD17B10 (0.45) | KMT2AALDH1A1MEN1MAPTLMNA | |
| SCHEMBL28199450 | 0.71 | AR (0.47) | NOTUM | |
| SCHEMBL23211918 | 0.71 | AKR1C3 (0.54) | TTRKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL22669019 | 0.71 | AKR1C3 (0.54) | TTRKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL30407607 | 0.71 | AKR1C3 (0.54) | TTRKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL4069223 | 0.70 | AKR1C3 (0.43) | TTRKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL10199935 | 0.70 | NPSR1 (0.32) | ALDH1A1MAPTTDP1KDM4EPOLB | |
| SCHEMBL28303004 | 0.70 | DRD2 (0.47) | KMT2AALDH1A1MAPTLMNACYP1A2 | |
| SCHEMBL27647544 | 0.69 | AKR1C3 (0.53) | TTRKMT2AMEN1MAPK1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369887-B1 | Use of trifluoromethyl phenyl-tetrahydropyridines in the manufacture of a medicament for the treatment of anxio-depressive disorders | SANOFI SA (FR) | 1995-06-21 | — | — | EP | claimed |
| EP-0412901-B1 | USE OF TRIFLUOROMETHYL-PHENYLTETRAHYDROPYRIDINES FOR THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF INTESTINAL MOTILITY | ELF SANOFI (FR) | 1993-05-05 | — | — | EP | claimed |
| US-5026716-A | Method of treatment of anxiety and anxio-depressive disorders | SANOFI (FR) | 1991-06-25 | — | — | US | claimed |
| EP-0412901-A2 | Use of trifluoromethyl-phenyltetrahydropyridines for the manufacture of medicaments for the treatment of intestinal motility | ELF SANOFI (FR) | 1991-02-13 | — | — | EP | claimed |
| EP-0369887-A2 | Use of trifluoromethyl phenyl-tetrahydropyridines in the manufacture of a medicament for the treatment of anxio-depressive disorders | SANOFI (FR) | 1990-05-23 | — | — | EP | claimed |
| JP-2256663-A | — | — | None | — | — | JP | disclosed |
| JP-3077824-A | — | — | None | — | — | JP | disclosed |
| JP-4226959-A | — | — | None | — | — | JP | disclosed |
| EP-0979079-B1 | USE OF TETRAHYDROPYRIDINE DERIVATIVES TO PREPARE MEDICINES FOR TREATING DISEASES CAUSING DEMYELINATION | SANOFI SYNTHELABO (FR) | 2004-06-16 | — | — | EP | disclosed |
| US-6344464-B1 | Use of tetrahydropyridine derivatives to prepare medicines for treating diseases causing demyelination | SANOFI-SYNTHELABO (FR) | 2002-02-05 | — | — | US | disclosed |
| EP-0950049-B1 | DIPHENYL ALKYL-TETRAHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI SYNTHELABO (FR) | 2001-10-17 | — | — | EP | disclosed |
| EP-0979079-A1 | USE OF TETRAHYDROPYRIDINE DERIVATIVES TO PREPARE MEDICINES FOR TREATING DISEASES CAUSING DEMYELINATION | SANOFI-SYNTHELABO (FR) | 2000-02-16 | — | — | EP | disclosed |
| EP-0369887-A2 | Use of trifluoromethyl phenyl-tetrahydropyridines in the manufacture of a medicament for the treatment of anxio-depressive disorders | SANOFI (FR) | 1990-05-23 | — | — | EP | disclosed |
| US-4602024-A | Substituted trifluoromethylphenyltetrahydropyridines having a cyano substituent and an anorectic activity, a process for preparing same and pharmaceutical compositions | SANOFI (FR) | 1986-07-22 | — | — | US | disclosed |
| EP-0101381-B1 | ANOREXIC TRIFLUOROMETHYL PHENYL TETRAHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI S.A. (FR) | 1985-12-04 | — | — | EP | disclosed |
| US-4521428-A | Anorexigenic trifluoromethylphenyltetrahydropyridines and pharmaceutical compositions containing them | SANOFI (FR) | 1985-06-04 | — | — | US | disclosed |
| EP-0060176-B1 | SUBSTITUTED TRIFLUOROMETHYLPHENYLTETRAHYDROPYRIDINES HAVING ANORECTIC ACTIVITY, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI S.A. (FR) | 1985-01-02 | — | — | EP | disclosed |
| US-4472408-A | Substituted trifluoromethylphenyltetrahydropyridines having an anorectic activity | SANOFI (FR) | 1984-09-18 | — | — | US | disclosed |
| EP-0101381-A1 | Anorexic trifluoromethyl phenyl tetrahydropyridines, process for their preparation and pharmaceutical compositions containing them | SANOFI S.A. (FR) | 1984-02-22 | — | — | EP | disclosed |
| EP-0060176-A1 | Substituted trifluoromethylphenyltetrahydropyridines having anorectic activity, their preparation and pharmaceutical compositions containing them | SANOFI S.A. (FR) | 1982-09-15 | — | — | EP | disclosed |