Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | RAD52 | P43351 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | APP | P05067 | 3/20 | 0.47 |
| ▸ | ACHE | P22303 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6651230 | 0.92 | APP (0.47) | KMT2APOLBRAD52SMN1; SMN2APP | |
| SCHEMBL6652588 | 0.90 | POLB (0.56) | KMT2APOLBRAD52SMN1; SMN2APP | |
| SCHEMBL6653990 | 0.87 | LMNA (0.45) | SMN1; SMN2ACHEKDM4EALDH1A1HPGD | |
| SCHEMBL6655631 | 0.84 | APP (0.44) | KMT2APOLBRAD52SMN1; SMN2APP | |
| SCHEMBL7553839 | 0.82 | APP (0.49) | KMT2APOLBRAD52SMN1; SMN2APP | |
| SCHEMBL7646678 | 0.80 | KMT2A (0.61) | KMT2APOLBRAD52SMN1; SMN2APP | |
| SCHEMBL6651408 | 0.79 | ALDH1A1 (0.48) | KMT2APOLBRAD52SMN1; SMN2APP | |
| SCHEMBL6652586 | 0.78 | KMT2A (0.60) | KMT2APOLBRAD52SMN1; SMN2APP | |
| SCHEMBL9821131 | 0.77 | KMT2A (0.59) | KMT2APOLBRAD52SMN1; SMN2APP | |
| SCHEMBL6653145 | 0.77 | CTNNB1 (0.36) | KMT2APOLBAPPMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218401-B1 | 4-BENZYLAMINOQUINOLINE CONJUGATES WITH BILE ACID AND THEIR HETEROANALOGUES, METHODS FOR PRODUCING THE SAME, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THEIR USE | AVENTIS PHARMA GMBH (DE) | 2004-06-16 | — | — | EP | disclosed |
| EP-1218401-A1 | 4-BENZYLAMINOQUINOLINE CONJUGATES WITH BILE ACID AND THEIR HETEROANALOGUES, METHODS FOR PRODUCING THE SAME, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THEIR USE | Aventis Pharma Deutschland GmbH (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021642-A1 | 4-BENZYLAMINOQUINOLINE CONJUGATES WITH BILE ACID AND THEIR HETEROANALOGUES, METHODS FOR PRODUCING THE SAME, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THEIR USE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-03-29 | — | — | WO | disclosed |