Trolamine

Trolamine

SCHEMBL6654624

O=C(O)CCC(=O)O.OCCN(CCO)CCO.[Fe]

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4

The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 known ✓ P08172 1/20 0.38
SLC6A2 known ✓ P23975 1/20 0.38
SLC6A4 known ✓ P31645 1/20 0.38
DRD3 known ✓ P35462 1/20 0.38
LMNA P02545 5/20 0.50
EGLN1 Q9GZT9 4/20 0.50
ALKBH5 Q6P6C2 1/20 0.50
SUCNR1 Q9BXA5 1/20 0.50
CAMK2A Q9UQM7 1/20 0.46
GPR84 Q9NQS5 1/20 0.42
FFAR1 O14842 1/20 0.42
FFAR4 Q5NUL3 1/20 0.42
KDM4E B2RXH2 3/20 0.39
ALOX15 P16050 2/20 0.39
MAPT P10636 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
TDP1 Q9NUW8 2/20 0.39
EYA2 O00167 1/20 0.39
APP P05067 1/20 0.39
ACE P12821 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trolamine SCHEMBL5874464 0.97 LMNA (0.53) LMNAEGLN1ALKBH5SUCNR1CAMK2A
Trolamine SCHEMBL8626759 0.97 LMNA (0.53) LMNAEGLN1ALKBH5SUCNR1CAMK2A
Trolamine SCHEMBL28237542 0.94 LMNA (0.50) LMNAEGLN1ALKBH5SUCNR1CAMK2A
Trolamine SCHEMBL11791924 0.89 CAMK2A (0.46) LMNAEGLN1ALKBH5SUCNR1CAMK2A
SCHEMBL5067889 0.89 CAMK2A (0.46) LMNAEGLN1ALKBH5SUCNR1CAMK2A
SCHEMBL563771 0.89 CAMK2A (0.46) LMNAEGLN1ALKBH5SUCNR1CAMK2A
Trolamine SCHEMBL5874784 0.86 SLC22A6 (0.58) LMNAEGLN1ALKBH5SUCNR1CAMK2A
Adipic Acid SCHEMBL5875290 0.86 GPR84 (0.59) LMNACAMK2AGPR84FFAR1FFAR4
SCHEMBL21513124 0.86 TDP1 (0.43) LMNAEGLN1ALKBH5SUCNR1CAMK2A
Adipic Acid SCHEMBL11579435 0.86 GPR84 (0.59) LMNACAMK2AGPR84FFAR1FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2964721-B1 METHOD OF FRACTURING WITH LIQUEFIED NATURAL GAS BAKER HUGHES HOLDINGS LLC (US) 2021-04-07 EP disclosed
US-10822935-B2 Method of treating a subterranean formation with natural gas BAKER HUGHES, A GE COMPANY, LLC (US) 2020-11-03 US disclosed
US-20180291719-A1 METHOD OF FRACTURING WITH NATURAL GAS BAKER HUGHES HOLDINGS LLC 2018-10-11 US disclosed
US-10012062-B2 Method of fracturing with liquefied natural gas BAKER HUGHES, A GE COMPANY, LLC (US) 2018-07-03 US disclosed
EP-2964721-A1 METHOD OF FRACTURING WITH LIQUEFIED NATURAL GAS Baker Hughes Incorporated (US) 2016-01-13 EP disclosed
WO-2014137625-A1 METHOD OF FRACTURING WITH LIQUEFIED NATURAL GAS BAKER HUGHES INCORPORATED (US) 2014-09-12 WO disclosed
US-20140246199-A1 METHOD OF FRACTURING WITH LIQUEFIED NATURAL GAS BAKER HUGHES HOLDINGS LLC 2014-09-04 US disclosed
EP-0871685-B1 PREPARATION OF HYDROCARBON GELS FROM FERRIC SOURCES, POLYCARBOXYLIC ACID COMPOUNDS, AND OPTIONAL AMINES, IN COMBINATION WITH PHOSPHATE ESTERS CLEARWATER INT LLC (US) 2004-06-30 EP disclosed
EP-0871685-A4 PREPARATION OF HYDROCARBON GELS FROM FERRIC SOURCES, POLYCARBOXYLIC ACID COMPOUNDS, AND OPTIONAL AMINES, IN COMBINATION WITH PHOSPHATE ESTERS CLEARWATER INC (US) 2000-02-23 EP disclosed
EP-0871685-A1 PREPARATION OF HYDROCARBON GELS FROM FERRIC SOURCES, POLYCARBOXYLIC ACID COMPOUNDS, AND OPTIONAL AMINES, IN COMBINATION WITH PHOSPHATE ESTERS CLEARWATER, INC. (US) 1998-10-21 EP disclosed
WO-1998020088-A1 PREPARATION OF HYDROCARBON GELS FROM FERRIC SOURCES, POLYCARBOXYLIC ACID COMPOUNDS, AND OPTIONAL AMINES, IN COMBINATION WITH PHOSPHATE ESTERS CLEARWATER, INC. (US) 1998-05-14 WO disclosed
US-5647900-A HYDROCARBON FRACTURING LIQUID, PHOSPHATE, FERRIC IRON TO FORM GEL AND POLYCARBOXYLIC ACID OR SALTS THEN FRACTURING CLEARWATER, INC. (US) 1997-07-15 US disclosed