Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARK7 | Q99497 | 1/20 | 0.57 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 8/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | PLG | P00747 | 2/20 | 0.46 |
| ▸ | KLK1 | P06870 | 2/20 | 0.46 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL666087 | 0.81 | PARK7 (0.64) | PARK7NPC1RAB9AMEN1KMT2A | |
| Dehydroxymethylepoxyquinomicin SCHEMBL14504317 | 0.80 | PARK7 (0.54) | PARK7P2RX1P2RX4P2RX7NPC1 | |
| Dehydroxymethylepoxyquinomicin SCHEMBL1671089 | 0.80 | PARK7 (0.54) | PARK7P2RX1P2RX4P2RX7NPC1 | |
| Dehydroxymethylepoxyquinomicin SCHEMBL1669417 | 0.80 | PARK7 (0.54) | PARK7P2RX1P2RX4P2RX7NPC1 | |
| Dehydroxymethylepoxyquinomicin SCHEMBL14491796 | 0.80 | PARK7 (0.54) | PARK7P2RX1P2RX4P2RX7NPC1 | |
| SCHEMBL665288 | 0.79 | PARK7 (0.53) | PARK7P2RX1P2RX4P2RX7KLK1 | |
| SCHEMBL115782 | 0.79 | PARK7 (0.51) | PARK7P2RX1NPC1RAB9AMEN1 | |
| SCHEMBL666528 | 0.75 | PARK7 (0.50) | PARK7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL666669 | 0.73 | PARK7 (0.53) | PARK7P2RX1P2RX4P2RX7NPC1 | |
| SCHEMBL116115 | 0.73 | PARK7 (0.53) | PARK7NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046357-A1 | Benzamide and Napthamide Derivatives Inhibiting Nuclear Factor-Kappa (B) - (NK-kB) | PROFECTUS BIOSCIENCES, INC. (US) | 2012-02-23 | — | — | US | claimed |
| EP-2443103-A1 | OXABICYCLO [4.1.O]HEPT-B-EN-S-YLCARBAMOYL DERIVATIVES INHIBITING THE NUCLEAR FACTOR-KAPPA(B) - (NF-KB) | Profectus Biosciences, Inc. (US) | 2012-04-25 | — | — | EP | disclosed |
| US-20120088827-A1 | Oxabicyclo[4.1.0]Hept-B-en-S-yl Carbamoyl Derivatives Inhibiting The Nuclear Factor-Kappa (B) - (NF-KB) | PROFECTUS BIOSCIENCES, INC. (US) | 2012-04-12 | — | — | US | disclosed |
| US-20120046357-A1 | Benzamide and Napthamide Derivatives Inhibiting Nuclear Factor-Kappa (B) - (NK-kB) | PROFECTUS BIOSCIENCES, INC. (US) | 2012-02-23 | — | — | US | disclosed |
| WO-2010148042-A1 | OXABICYCLO [4.1.O]HEPT-B-EN-S-YLCARBAMOYL DERIVATIVES INHIBITING THE NUCLEAR FACTOR-KAPPA(B) - (NF-KB) | PROFECTUS BIOSCIENCES, INC. (US) | 2010-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046357-A1 | Benzamide and Napthamide Derivatives Inhibiting Nuclear Factor-Kappa (B) - (NK-kB) | NFKBIA, IKBKB, NFKB1 | PARK7 3384/4885P2RX1 855/4885P2RX3 1141/4885 |
| US-20120088827-A1 | Oxabicyclo[4.1.0]Hept-B-en-S-yl Carbamoyl Derivatives Inhibiting The Nuclear Factor-Kappa (B) - (NF-KB) | NFKBIA, NFRKB, IKBKB | PARK7 3595/4885P2RX1 4295/4885P2RX3 4501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.