SCHEMBL6655419

SCHEMBL6655419

COc1ccc(/C(C)=C/C(=O)O)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 5/20 0.59
CA2 P00918 5/20 0.59
NR4A1 P22736 1/20 0.56
NR4A2 P43354 1/20 0.56
NR4A3 Q92570 1/20 0.56
CES2 O00748 2/20 0.55
CES1 P23141 2/20 0.55
CYP1A2 P05177 1/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2C19 P33261 1/20 0.53
PARP1 P09874 1/20 0.52
PARP10 Q53GL7 1/20 0.52
PARP2 Q9UGN5 1/20 0.52
PARP4 Q9UKK3 1/20 0.52
MAPT P10636 1/20 0.52
NQO2 P16083 2/20 0.51
PTGS1 P23219 1/20 0.50
PTGS2 P35354 1/20 0.50
ALDH1A1 P00352 1/20 0.50
THRB P10828 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6655424 1.00 CA1 (0.59) CA1CA2NR4A1NR4A2NR4A3
SCHEMBL6655426 1.00 CA1 (0.59) CA1CA2NR4A1NR4A2NR4A3
Hydrochloric Acid SCHEMBL9445571 0.98 CA1 (0.57) CA1CA2NR4A1NR4A2NR4A3
SCHEMBL29629259 0.85 CYP1A2 (0.67) CA1CA2CES2CES1CYP1A2
SCHEMBL6962047 0.84 KDM4E (0.65) CA1CA2CYP1A2CYP3A4CYP2C19
SCHEMBL6962052 0.84 KDM4E (0.65) CA1CA2CYP1A2CYP3A4CYP2C19
SCHEMBL6962058 0.84 KDM4E (0.65) CA1CA2CYP1A2CYP3A4CYP2C19
Hydrochloric Acid SCHEMBL6785127 0.83 KDM4E (0.63) CA1CA2CYP1A2CYP3A4CYP2C19
SCHEMBL9183363 0.83 CA1 (0.55) CA1CA2CES2CES1CYP1A2
SCHEMBL9820463 0.83 ELANE (0.59) NR4A1NR4A2NR4A3CYP3A4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 160 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240294465-A1 NOVEL ANTI-FIBROTIC DRUGS HELMHOLTZ ZENTRUM MÜNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (DE) 2024-09-05 US disclosed
CN-118339029-A Special plastic film for preparing security documents 科思创德国股份有限公司 2024-07-12 CN disclosed
CN-115461396-B Additive composition and use thereof, condensation polymer composition, molding compound prepared from same and molded part and use thereof 弗劳恩霍夫应用研究促进协会 2024-07-12 CN disclosed
CN-118234793-A Stabilizer based on syringic acid, vanillic acid, isovanillic acid or 5-hydroxyveratric acid, plastic composition, method for stabilizing a plastic composition and stabilizer composition 弗劳恩霍夫应用研究促进协会 2024-06-21 CN disclosed
CN-118165743-A Polymerizable oligomeric liquid crystals, polymerizable medium and polymerized liquid crystal films 默克专利股份有限公司 2024-06-11 CN disclosed
CN-118063856-A Flame retardant mixtures 科莱恩国际有限公司 2024-05-24 CN disclosed
CN-117999310-A Stabilizer formulation 巴斯夫欧洲公司 2024-05-07 CN disclosed
CN-117897427-A Stabilizer combinations for preventing degradation of synthetic polymers 巴斯夫欧洲公司 2024-04-16 CN disclosed
CN-113614138-B Two-component polyurethane coating with improved pot life without loss of weatherability 科思创知识产权两合公司 2024-03-29 CN disclosed
CN-117715965-A Improved polymer compositions 杜邦聚合物公司 2024-03-15 CN disclosed
CN-105636954-B Triazine, piperidine and pyrrolidinyl hindered amine light stabilizers 巴斯夫欧洲公司 2019-12-13 CN disclosed
US-20040254241-A1 Enzyme inhibitor; cognition activators KYOWA HAKKO KOGYO CO., LTD. (JP) 2004-12-16 US disclosed
CN-1531567-A Polycarbonates with significant shear thinning behavior 2004-09-22 CN disclosed
EP-1431280-A1 ARYL SULFAMATE DERIVATIVES Kyowa Hakko Kogyo Co., Ltd (JP) 2004-06-23 EP disclosed
CN-1501952-A Polycarbonates having a low shear thinning ratio 2004-06-02 CN disclosed
CN-1437630-A Stabilizer mixture CIBA SC HOLDING AG (CH) 2003-08-20 CN disclosed
US-RE36625-E Linear and cyclic polymers or oligomers having a photoreactive ethene group ROLIC AG (CH) 2000-03-21 US disclosed
US-6004988-A Carboxylic acid derivatives, their preparation and their use BASF AKTIENGESELLSCHAFT (DE) 1999-12-21 US disclosed
EP-0861847-A2 Stabilizer composition and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-09-02 EP disclosed
US-5539074-A LIQUID CRYSTAL POLYMERS ON SILICA FOR LIGHT SENSITIVE ELEMENTS HOFFMANN-LA ROCHE INC. (US) 1996-07-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040254241-A1 Enzyme inhibitor; cognition activators SULT1A1, STS, CYP26A1 CA1 147/4885CA2 465/4885NR4A1 90/4885
US-20240294465-A1 NOVEL ANTI-FIBROTIC DRUGS FAH, ACAT2, FIBP CA1 1583/4885CA2 470/4885NR4A1 1559/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.