Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 12/20 | 0.59 |
| ▸ | MMP9 | P14780 | 4/20 | 0.44 |
| ▸ | MMP13 | P45452 | 4/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 8/20 | 0.41 |
| ▸ | PTGES | O14684 | 3/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 6/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6654293 | 0.89 | ADAM17 (0.70) | ADAM17MMP9MMP13MMP1 | |
| SCHEMBL6787275 | 0.85 | ADAM17 (0.62) | ADAM17MMP9MMP13ALOX5PTGES | |
| SCHEMBL6657581 | 0.83 | ADAM17 (0.78) | ADAM17MMP9MMP13ALOX5MMP1 | |
| SCHEMBL6656809 | 0.81 | ADAM17 (0.63) | ADAM17MMP9MMP13ALOX5PTGES | |
| SCHEMBL6657088 | 0.78 | ADAM17 (0.65) | ADAM17MMP9MMP13MMP1PPARA | |
| SCHEMBL6656399 | 0.76 | ADAM17 (0.62) | ADAM17MMP9MMP13ALOX5PTGES | |
| SCHEMBL6654467 | 0.76 | ADAM17 (0.65) | ADAM17MMP9MMP13ALOX5PTGES | |
| SCHEMBL6659002 | 0.76 | ADAM17 (0.77) | ADAM17MMP9MMP13MMP1 | |
| SCHEMBL6661896 | 0.76 | ALOX5 (0.46) | ALOX5PTGESPPARG | |
| SCHEMBL6658123 | 0.75 | ADAM17 (0.64) | ADAM17MMP9MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | WYETH CORP (US) | 2004-07-21 | — | — | EP | disclosed |