Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 10/20 | 0.44 |
| ▸ | MMP9 | P14780 | 3/20 | 0.38 |
| ▸ | MMP13 | P45452 | 3/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6655286 | 0.87 | ADAM17 (0.51) | ADAM17MMP9MMP13MMP1 | |
| SCHEMBL6656959 | 0.84 | ADAM17 (0.52) | ADAM17MMP9MMP13MMP1KMT2A | |
| SCHEMBL6656714 | 0.84 | ADAM17 (0.45) | ADAM17MMP9MMP13MMP1PPARA | |
| SCHEMBL6654871 | 0.83 | ADAM17 (0.43) | ADAM17MMP9MMP13MMP1 | |
| SCHEMBL6660841 | 0.83 | MAOB (0.43) | ADAM17MMP9MMP13KMT2A | |
| SCHEMBL6662479 | 0.83 | ADAM17 (0.44) | ADAM17MMP9MMP13POLBMEN1 | |
| SCHEMBL6658036 | 0.78 | PSMB5 (0.39) | ADAM17MMP9MMP13MMP1PPARG | |
| SCHEMBL7323999 | 0.77 | ADAM17 (0.46) | ADAM17MMP9MMP13MMP1 | |
| SCHEMBL6656469 | 0.75 | ADAM17 (0.56) | ADAM17MMP9MMP13MMP1 | |
| SCHEMBL7960647 | 0.72 | AGXT (0.53) | ADAM17MMP13PPARGNCOA2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | WYETH CORP (US) | 2004-07-21 | — | — | EP | disclosed |