Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 9/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6656714 | 0.89 | ADAM17 (0.45) | ADAM17ALDH1A1RAB9AMMP9MMP13 | |
| SCHEMBL6656959 | 0.89 | ADAM17 (0.52) | ADAM17ALDH1A1KMT2AMMP9MMP13 | |
| SCHEMBL6655286 | 0.88 | ADAM17 (0.51) | ADAM17MMP9MMP13 | |
| SCHEMBL6660841 | 0.86 | MAOB (0.43) | ADAM17KMT2AMMP9MMP13MAOA | |
| SCHEMBL6656661 | 0.83 | ADAM17 (0.44) | ADAM17KMT2AMEN1RAB9AMMP9 | |
| SCHEMBL6658036 | 0.81 | PSMB5 (0.39) | ADAM17MMP9MMP13SMN1; SMN2KDM4E | |
| SCHEMBL6654871 | 0.80 | ADAM17 (0.43) | ADAM17MMP9MMP13MAOAMAOB | |
| SCHEMBL6656469 | 0.78 | ADAM17 (0.56) | ADAM17MMP9MMP13 | |
| SCHEMBL6659307 | 0.73 | ADAM17 (0.53) | ADAM17MMP9MMP13POLB | |
| SCHEMBL6656624 | 0.72 | LTA4H (0.49) | ALDH1A1RAB9ATDP1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | WYETH CORP (US) | 2004-07-21 | — | — | EP | disclosed |
| US-6340691-B1 | TREATMENT OF ARTHRITIS, TUMOR METASTASIS, TISSUE ULCERATION, ABNORMAL WOUND HEALING, PERIODONTAL DISEASE, BONE DISEASE, DIABETES (INSULIN RESISTANCE) AND HIV INFECTION | AMERICAN CYANAMID COMPANY | 2002-01-22 | — | — | US | disclosed |