Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 15/20 | 0.51 |
| ▸ | MMP13 | P45452 | 8/20 | 0.42 |
| ▸ | MMP9 | P14780 | 8/20 | 0.42 |
| ▸ | MMP1 | P03956 | 8/20 | 0.42 |
| ▸ | MMP2 | P08253 | 3/20 | 0.39 |
| ▸ | MMP14 | P50281 | 3/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6656959 | 0.89 | ADAM17 (0.52) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6656714 | 0.89 | ADAM17 (0.45) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6662479 | 0.88 | ADAM17 (0.44) | ADAM17MMP13MMP9 | |
| SCHEMBL6656661 | 0.87 | ADAM17 (0.44) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6660841 | 0.86 | MAOB (0.43) | ADAM17MMP13MMP9ALOX5 | |
| SCHEMBL6654871 | 0.86 | ADAM17 (0.43) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6658036 | 0.83 | PSMB5 (0.39) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6656469 | 0.80 | ADAM17 (0.56) | ADAM17MMP13MMP9MMP1MMP14 | |
| SCHEMBL6659307 | 0.75 | ADAM17 (0.53) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL28294905 | 0.73 | ALDH1A1 (0.45) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | WYETH CORP (US) | 2004-07-21 | — | — | EP | disclosed |