Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 5/20 | 0.62 |
| ▸ | MMP13 | P45452 | 4/20 | 0.62 |
| ▸ | MMP2 | P08253 | 3/20 | 0.59 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4060719 | 1.00 | MMP12 (0.62) | MMP12MMP13MMP2ADAM17 | |
| SCHEMBL4060723 | 1.00 | MMP12 (0.62) | MMP12MMP13MMP2ADAM17 | |
| SCHEMBL4057870 | 0.93 | MMP12 (0.67) | MMP12MMP13MMP2ADAM17 | |
| SCHEMBL4057875 | 0.93 | MMP12 (0.67) | MMP12MMP13MMP2ADAM17 | |
| SCHEMBL4056914 | 0.90 | ADAM17 (0.51) | MMP12MMP13ADAM17 | |
| SCHEMBL4056911 | 0.90 | ADAM17 (0.51) | MMP12MMP13ADAM17 | |
| SCHEMBL4050725 | 0.89 | MMP12 (0.71) | MMP12MMP13MMP2ADAM17 | |
| SCHEMBL4050722 | 0.89 | MMP12 (0.71) | MMP12MMP13MMP2ADAM17 | |
| SCHEMBL4442027 | 0.88 | MMP13 (0.65) | MMP12MMP13MMP2ADAM17 | |
| SCHEMBL4442031 | 0.88 | MMP13 (0.65) | MMP12MMP13MMP2ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397137-A4 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL MYERS SQUIBB CO (US) | 2004-10-13 | — | — | EP | disclosed |
| EP-1397137-A1 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002096426-A1 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-12-05 | — | — | WO | disclosed |