Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952329 | 0.86 | ESR2 (0.39) | ESR2NR1H2MAPK1USP2SMN1; SMN2 | |
| SCHEMBL4947670 | 0.83 | ESR2 (0.44) | ESR2NR1H2MAPK1USP2SMN1; SMN2 | |
| SCHEMBL6659330 | 0.82 | ESR2 (0.43) | ESR2NR1H2MAPK1USP2SMN1; SMN2 | |
| SCHEMBL13146164 | 0.82 | NR1H2 (0.45) | ESR2NR1H2MAPK1USP2SMN1; SMN2 | |
| SCHEMBL38665539 | 0.82 | ESR2 (0.43) | ESR2NR1H2MAPK1USP2SMN1; SMN2 | |
| SCHEMBL29120638 | 0.81 | ESR2 (0.42) | ESR2NR1H2MAPK1USP2SMN1; SMN2 | |
| SCHEMBL6664071 | 0.80 | PTPN1 (0.35) | SMN1; SMN2MAPTALDH1A1LMNAPTPN1 | |
| SCHEMBL29358867 | 0.80 | NR1H2 (0.43) | ESR2NR1H2MAPK1USP2SMN1; SMN2 | |
| SCHEMBL1673622 | 0.79 | ESR2 (0.43) | ESR2NR1H2MAPK1ALDH1A1GPR119 | |
| SCHEMBL7745371 | 0.79 | SMN1; SMN2 (0.45) | NR1H2MAPK1SMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080075-B1 | PIPERIDIDINYL AND N-AMIDINOPIPERIDINYL DERIVATIVES | AVENTIS PHARMA INC (US) | 2004-08-11 | — | — | EP | disclosed |
| US-20040067988-A1 | Piperididinyl and N-amidinopiperidinyl derivatives | AVENTIS PHARMACEUTICALS INC. (US) | 2004-04-08 | — | — | US | disclosed |
| US-20020016339-A1 | Piperididinyl and N-amidinopiperidinyl derivatives | KLEIN SCOTT I (US) | 2002-02-07 | — | — | US | disclosed |
| US-6277865-B1 | ANTICOAGULANTS | AVENTIS PHARMACEUTICALS PRODUCTS INC. | 2001-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020016339-A1 | Piperididinyl and N-amidinopiperidinyl derivatives | F11, F5, TFPI | ESR2 3380/4885NR1H2 1089/4885MAPK1 3046/4885 |
| US-20040067988-A1 | Piperididinyl and N-amidinopiperidinyl derivatives | TFPI, F2, SERPINC1 | ESR2 2570/4885NR1H2 1774/4885MAPK1 2899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.